Welcome to Gimelbrant lab

Establishment and maintenance of active or inactive chromatin states are fundamental processes in metazoan biology.  In mammals, two well-known classes of epigenetic gene silencing are imprinting and X chromosome inactivation.  Our research has shown that each pair of autosomes has multiple loci behaving in a manner similar to X inactivation.

Research in the laboratory is focused on the questions concerning allele-specific reguation of gene expression, particularly in the genes subject to "random" monoallelic expression (MAE).