Welcome to Gimelbrant lab
Establishment and maintenance of active or inactive chromatin states are fundamental processes in metazoan biology. In mammals, two well-known classes of epigenetic gene silencing are imprinting and X chromosome inactivation. Our research has shown that each pair of autosomes has multiple loci behaving in a manner similar to X inactivation.
Research in the laboratory is focused on the questions concerning allele-specific reguation of gene expression, particularly in the genes subject to "random" monoallelic expression (MAE).